• The repair pathway of DNA DSBs through

  2020-08-09

  

  The repair pathway of DNA-DSBs through HR and the role of BRCA1 in repair kinetics by HR is also an important factor to unravel the radiation sensitization of novel small molecule inhibitors. The involvement of the breast cancer susceptibility gene 1 (BRCA1) in tumorigenesis and its role in facilita

• br Discussion br Conflicts of interest br Acknowledgment

  2020-08-08

  

  Discussion Conflicts of interest Acknowledgment Introduction To maximize the benefits and minimize the toxicity of an oncotherapy, targeted therapy has emerged as one of the major modalities for cancer control, with impressive results obtained for a number of cancers. These targets are e

• br EphB as a therapeutic target in aerodigestive cancers

  2020-08-08

  

  EphB4 as a therapeutic target in aerodigestive cancers Pharmacologically targeting EphB4 Biomarker potential Comparatively speaking, very little is known about the potential of EphB4 as a biomarker, especially in upper aerodigestive malignancies. A recent study by Yu et al. [75] who evaluat

• In order to reveal if the duration

  2020-08-08

  

  In order to reveal if the duration of FGE reaction time would have an effect on the extent of substrate sequence modification, the individual phage 4(1), 4(2), 4(3), and NC were again screened as above using different FGE reaction times of 60, 180, and 300min. From Fig. 3b, we see that indeed the lo

• br EBI An Endogenous TM Receptor Manipulated by

  2020-08-07

  

  EBI2: An Endogenous 7TM Receptor Manipulated by EBV EBI2 was identified in 1993, when Kieff and colleagues used subtractive hybridization of DNA from Burkitt\'s lymphoma cells to screen for upregulated genes in EBV-infected cells. They found, being more than 200-fold upregulated (hence the name:

• Until recently the first line treatment of RLS

  2020-08-07

  

  Until recently, the first line treatment of RLS was the administration of low dose of three dopaminergic drugs, which has been approved by the US Food and Drug Administration and the European Medicines Agency for the treatment of moderate to severe RLS. These compounds are pramipexole (Mirapex), rop

• The in vitro studies support our previous

  2020-08-06

  

  The in vitro studies support our previous observations of a bimodal expression pattern of B. malayi transcripts after tetracycline treatment, including the two enzymes we studied here. We hypothesize that this bimodal expression may be due to stage-specific responses of the host in response to Wolba

• Introduction Eicosanoid lipid prostaglandin D PGD is the maj

  2020-08-06

  

  Introduction Eicosanoid lipid prostaglandin D2 (PGD2) is the major prostaglandin produced by activated mast AI-10-49 (Lewis and Austen, 1981). The physiological function of PGD2 is mainly mediated by two G protein-coupled receptors (GPCRs), PGD2 receptor 1 and 2 (DP1 and DP2), which share modest s

• br Material and methods br Results br Discussion This study

  2020-08-06

  

  Material and methods Results Discussion This study was performed to investigate the molecular correlates of addiction in a model based on the development of psychomotor sensitization which takes place after repeated nicotine administrations (Carboni et al., 2016; Vezina et al., 2007; Zivian

• Researches aforementioned provide effective numerical theore

  2020-08-06

  

  Researches aforementioned provide effective numerical/theoretical descriptions of expansion behavior of PELE when small-caliber projectiles penetrating thin target at high impact velocity. Here we presented a similar study on large-caliber PELE projectile (130 mm) with various thickness steel jacket

• A generally applicable strategy to

  2020-08-06

  

  A generally applicable strategy to screen for improved α-KGD activity could be based on the generation of succinate by the decarboxylation of α-KG [49]. In this context, Escherichia coli strains were engineered, in which succinate-producing enzymes from the TCA (3S,5S)-Atorvastatin sodium salt austr

• br Acknowledgements br Introduction Botulinum neurotoxin BoN

  2020-08-05

  

  Acknowledgements Introduction Botulinum neurotoxin (BoNT) is a uniquely potent protein synthesized by Clostridium botulinum, C. baratii and C. butyricum, (Rosetto et al., 2014, Kukreja and Singh, 2014). It acts on cholinergic nerve endings and blocks the release of Ristocetin A sulfate synthes

• Using the juxtarenal PPE the

  2020-08-05

  

  Using the juxtarenal PPE, the induction of juxta- and suprarenal aneurysms is described herein (Fig. 3A). The infra-/suprarenal part of the Roxithromycin sale can now be investigated separately, taking into account different embryological backgrounds and varying reactivity to differing stimuli (revi

• br Acknowledgements This work was aided

  2020-08-05

  

  Acknowledgements This work was aided by discussions with R. Hietpas, P. Mishra, L. Jiang, C. R. Matthews, R. Gilmore, and P. Pryciak. We are grateful for assistance from the University of Massachusetts Medical School Core Flow Cytometry Laboratory and R. Konz with cell sorting experiments. This w

• The sulfonamide was important for the DP

  2020-08-05

  

  The sulfonamide was important for the DP activity: no potent dual antagonists were identified through the modification of this functional group. Multiple modifications of the phenylacetic Phusion high-fidelity DNA polymerase sale moiety have been reported, such as bioisoteric replacements of the car

14869 records 807/992 page Previous Next First page 上5页 806807808809810 下5页 Last page