• CU CPT 4a Natural progestogens play an important role

  2020-11-24

  

  Natural progestogens play an important role in the stimulation of oocyte growth and maturation as well as in spermatogenesis and sperm maturation, and they act as sex pheromones in teleost fish (Kime, 1990, Kobayashi et al., 2002, Nagahama and Yamashita, 2008, Scott et al., 2010). A complex series o

• Additionally although the membrane localized ER signaling de

  2020-11-24

  

  Additionally, although the membrane-localized ER signaling described in this review has generally been studied in isolation from nuclear signaling, it is becoming clearer and clearer that integration of these mechanisms must be considered (Frick, 2015). Perhaps the distinct estradiol signaling mecha

• Cantharidin is a natural element extracted

  2020-11-24

  

  Cantharidin is a natural element extracted from blister beetles, and has been proven to be effective in cancer [16]. NCTD, the demethylated analog of cantharidin, has been synthesized and been shown to have an equal anti-cancer effect with fewer side effects than cantharidin [39]. It was confirmed t

• br Methods Ventricular cardiomyocytes from adult male Wistar

  2020-11-24

  

  Methods Ventricular cardiomyocytes from adult male Wistar rats were isolated using a standard enzymatic digestion [11]. Cells were incubated at 37°C for 4 to 6h with Tyrode solution (in mM: 140 NaCl, 4 KCl, 1.1 MgCl2, 10 HEPES, 10 glucose, 1.8 CaCl2; pH7.4, with NaOH) supplemented or not with 10μ

• br Experimental section br Acknowledgments

  2020-11-24

  

  Experimental section Acknowledgments MIN6 cells were kindly provided by Dr. Junichi Miyazaki, Osaka University. This research was supported in part by the Ministry of Education, Culture, Sports, Science and Technology of Japan (JP16H05099 and JP18H04609 to K.H., and JP16H06574 to T.U.), SENTAN

• br Experimental Procedures br Author Contributions br Acknow

  2020-11-24

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Breast cancer is one of the most common malignancies for women worldwide, representing approximately 22% of women’s malignancies that pose a threat to women’s health [[1], [2], [3], [4]]. The morbidity rate of brea

• br Conclusions Mulan is a mitochondrial E

  2020-11-24

  

  Conclusions Mulan is a mitochondrial E3 ubiquitin ligase with diverse roles in cell growth, cell death, and mitophagy. To better understand the mechanism of Mulan's function we used a modified yeast two-hybrid system to isolate proteins that interact with its cytoplasmic RING domain (amino acids

• There are numerous theories of schizophrenia etiopathology a

  2020-11-23

  

  There are numerous theories of schizophrenia etiopathology and genetics is often taken into consideration [25]. The dopamine D2 receptor is important since it is blocked by typical antipsychotic drugs with high affinity which is correlated with the ability to control psychotic symptoms in schizophre

• br The major regulator of radiation sensitivity Tumor

  2020-11-23

  

  The major regulator of radiation sensitivity Tumor cell resistance to radiation is a big issue for radiation therapy, and a major concern of radiation oncologist. Understanding the regulation mechanism of radiation sensitivity is still a research hotspot. Increased sensitivity to ionizing radiati

• br Materials and methods br Results br Discussion br

  2020-11-23

  

  Materials and methods Results Discussion Conclusions First, we replicated the association of DDR1 with SZ in an independent Spanish sample and demonstrated that a SNP-SNP interaction within DDR1 played a role in the association with the disease. Second, we observed that SZ subjects with

• br Materials and methods br

  2020-11-23

  

  Materials and methods Results The frequency of hypermethylation of RARbeta, RASSF1A, FHIT, GSTP1, MGMT, VHL and DAPK in patients with primary LSCC was assessed in both the tumor tissue samples and macroscopically and histologically normal mucosa from distant sites of the surgical specimen, Que

• Arsenic could cause apoptosis in both benign and malignant

  2020-11-23

  

  Arsenic could cause apoptosis in both benign and malignant cells (Akao et al., 2000, Gupta et al., 2003, Namgung and Xia, 2001). However, at present, little is known about the consequences of arsenic-treated urothelial cells in autophagy and expression of its related proteins. In addition, the alter

• Defensins are one major class of antimicrobial

  2020-11-23

  

  Defensins are one major class of antimicrobial, cationic peptides that are released from fexofenadine hydrochloride and imbedded in the mucus layer on mucosal surfaces [45]. They can be categorized into two major families; α- and β-defensins. In humans there are two α-defensin members, defensin 5 (

• Therefore in this study we determined whether exogenous LTD

  2020-11-23

  

  Therefore, in this study we determined whether exogenous LTD, a potent agonist of both CysLT and CysLT receptors , , induces melatonin receptor agonists edema and AQP4 expression in mouse brain; if so, which subtype of the receptors is involved in AQP4 expression in mouse brain and the cultured rat

• The CysLT receptor antagonist BayCysLT RA significantly

  2020-11-23

  

  The CysLT2 receptor antagonist BayCysLT2RA significantly suppressed multiple antigen challenge-induced infiltration of eosinophils and mononuclear Amadacycline into the lung, indicating that CysLT2 receptor activation is involved in leukocyte migration. In contrast to the present finding, Barret et 

14877 records 755/992 page Previous Next First page 上5页 751752753754755 下5页 Last page