• We have previously shown that the human gonadotropins hLH an

  2025-01-17

  

  We have previously shown that the human gonadotropins hLH and hCG trigger a partly irreversible stimulation of intracellular cyclic AMP accumulation in mouse Leydig Tumor honokiol receptor (MLTC) in contrast to all other tested mammalian LHs and CG (Klett et al., 2016). In order to get a better insi

• The obtained results indicate that even

  2025-01-17

  

  The obtained results indicate that even when the impairment of the same forms of memory are present, amnesia can develop in different ways. Impairment of memory reconsolidation in the conditioned food aversion model through both the serotonin receptor antagonist and the antagonist of NMDA glutamate

• br Acknowledgements br Introduction Double stranded DNA brea

  2025-01-17

  

  Acknowledgements Introduction Double-stranded DNA breaks (DSBs) are among the most deleterious DNA lesions that threaten genomic integrity. DSBs are generated not only by exogenous DNA-damaging agents but also by normal cellular processes such as V(D)J recombination, meiosis, and DNA replicati

• br Results br Discussion ER and GR play opposite

  2025-01-17

  

  Results Discussion ER and GR play opposite phenotypic roles in the normal endometrium, with ER promoting growth and GR inhibiting growth. Here, we show that in endometrial cancer, GR expression is associated with worse outcomes and higher-grade tumors, and this association is observed only in

• Although the interactions of PhLP with G and its other

  2025-01-16

  

  Although the interactions of PhLP with Gβγ and its other partners have been convincingly documented through in vitro studies, it is not clear how PhLP controls nadph oxidase inhibitor signaling in vivo. C. elegans provides a powerful genetic model to analyze Phosducin function and study its interact

• Finally terbinafine is generally associated with a low index

  2025-01-16

  

  Finally, terbinafine is generally associated with a low index of toxicity and few adverse effects. In humans, only mild GI toxicity and hepatobiliary dysfunction are reported. In red-tailed hawks, oral administration of a high dose of terbinafine (120 mg/kg BW) was furthermore demonstrated to induce

• br Summary and future br Introduction Androgen activity is

  2025-01-16

  

  Summary and future Introduction Androgen activity is critical for a wide range of developmental and physiological responses and is especially important in male sexual differentiation and maturation. The biological activity of androgens occurs through binding to the androgen receptor (AR) and t

• Previous studies to investigate the functions

  2025-01-16

  

  Previous studies to investigate the functions of AHR in Treg Naringin have employed a loss-of-function approach, using AHR complete-null mice, or a gain-of-function approach by ligand administration. However, these approaches may confound the interpretation of the results. For example, the broad exp

• DAPI hydrochloride br A Rs which were

  2025-01-16

  

  A3Rs, which were cloned and then pharmacologically identified in the early 1990s, are expressed in multiple organs and peripheral tissues including DAPI hydrochloride involved in inflammatory responses (Gessi et al., 2008, Borea et al., 2014). While low levels are expressed in the CNS, A3R agonis

• Adenosine is a ubiquitous homeostatic substance released fro

  2025-01-16

  

  Adenosine is a ubiquitous homeostatic substance released from most cells, including neurons and glias. Endogenous adenosine acts at four principal G-protein-associated receptor subtypes: A1, A2a, A2b and A3 (Ralevic and Burnstock, 1998). The stimulation of adenosine receptors by extracellular adenos

• snap finance br Conclusions The following are the supplement

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  Conclusions The following are the supplementary data related to this article. Author contributions Conflict of interest Funding sources This work was supported by the Canadian Institutes of Health Research [grant: MOP-79470]. Introduction Sperm cells undergo a number of physical and

• MicroRNA miRNA is an abundant

  2025-01-16

  

  MicroRNA (miRNA) is an abundant group of small (22-nucleotide) noncoding RNA molecules that directly binds with 3′ untranslated region (UTR) of target messenger RNAs (mRNAs) to regulate gene expression, playing an important role in variety of biological processes including cell proliferation, apopto

• br Conclusions and future directions Translation of the

  2025-01-16

  

  Conclusions and future directions Translation of the therapy to human MG will require a substitute adjuvant for IFA. Most human vaccines use aluminum salts (alum) as adjuvants. Both IFA and alum selectively promote antibody dominated Th 2 immune responses, rather than T killer cell dominated Th 1

• NSAIDs induce gastrointestinal toxicity and evoke asthma by

  2025-01-16

  

  NSAIDs induce gastrointestinal toxicity and evoke er stress thapsigargin by decreasing the production of gastroprotective prostanoids and by redirecting the COX substrate AA into LT biosynthesis, thereby causing vasoconstriction in gastric mucosa and airways (Celotti and Laufer, 2001; Koeberle and W

• These results must also be

  2025-01-15

  

  These results must also be addressed in light of porcine AMPKγ3R200Q (RN−) mutation. Pigs harboring this mutation produce meat with an abnormally low ultimate pH (pHbuy ivermectin meat (Copenhafer et al., 2006, Lundström et al., 1998, Milan et al., 2000). This extremely low pH is very close to the

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