• Rewiring Chemoresistance: Mechanistic Insights and Strate...

  2025-10-02

  This thought-leadership article explores the evolving landscape of DNA synthesis inhibition in cancer research, with a focus on carboplatin’s mechanistic role in overcoming tumor resistance. Integrating new findings on cancer stem cell plasticity and m6A-mediated regulation, we outline actionable guidance for translational researchers aiming to enhance preclinical oncology workflows and develop next-generation therapeutic strategies.

• Afatinib: Precision Tyrosine Kinase Inhibitor for Advance...

  2025-10-01

  Afatinib (BIBW 2992) empowers cancer biology research by irreversibly inhibiting the ErbB family kinases, offering robust control within patient-derived tumor assembloid models. Its utility in dissecting EGFR, HER2, and HER4 signaling pathways uniquely positions it for next-generation drug screening, resistance mechanism analysis, and personalized therapy optimization.

• Rucaparib: A Potent PARP1 Inhibitor for Advanced DNA Dama...

  2025-09-30

  Rucaparib (AG-014699, PF-01367338) is a next-generation PARP inhibitor redefining DNA damage response research, particularly as a radiosensitizer for PTEN-deficient and ETS fusion-expressing prostate cancer cells. Its unique mechanism—potently inhibiting PARP1 and modulating regulated cell death pathways—offers researchers precision tools for dissecting base excision repair and apoptotic signaling in cancer biology.

• Leucovorin Calcium in Tumor Assembloids: A New Era for Me...

  2025-09-29

  Explore how Leucovorin Calcium, a pivotal folate analog, is transforming methotrexate rescue and antifolate drug resistance research in patient-derived tumor assembloid models. Gain unique insights into its mechanistic role in complex tumor microenvironments and advanced cell proliferation assays.

• Vancomycin in Experimental Immunology: Precision Modulati...

  2025-09-28

  Explore the advanced use of Vancomycin, a powerful glycopeptide antibiotic, as a precision tool in immunological and microbiome research. This article uniquely examines Vancomycin’s role in modulating Th1/Th2 balance and experimental design for bacterial resistance mechanisms.

• Anti Reverse Cap Analog (ARCA): Driving hiPSC Reprogrammi...

  2025-09-27

  Explore how Anti Reverse Cap Analog (ARCA), 3´-O-Me-m7G(5')ppp(5')G revolutionizes mRNA therapeutics research by enabling efficient, safe, and transgene-free reprogramming of human stem cells. Gain unique insights into ARCA’s role in advanced in vitro transcription and hiPSC-to-oligodendrocyte differentiation.

• Influenza Hemagglutinin (HA) Peptide: Precision Tagging f...

  2025-09-26

  Explore the Influenza Hemagglutinin (HA) Peptide as a premier molecular biology peptide tag for dissecting ubiquitination dynamics and protein signaling. This article uniquely integrates advanced workflow protocols and mechanistic insights, offering scientists a detailed roadmap for leveraging HA tag peptide technology in quantitative protein interaction studies.

• Cy5-UTP: Precision RNA Probe Labeling for LNP Trafficking...

  2025-09-25

  Discover how Cy5-UTP (Cyanine 5-uridine triphosphate) empowers next-generation RNA probe synthesis for advanced molecular biology, including LNP intracellular trafficking and dual-color expression analysis. Explore unique mechanisms, technical integration, and new research directions in fluorescent nucleotide analog applications.

• ABT-263 (Navitoclax): Illuminating Bcl-2 Inhibition for P...

  2025-09-24

  Explore how ABT-263 (Navitoclax), a potent Bcl-2 family inhibitor, enables advanced caspase-dependent apoptosis research and mitochondrial pathway analysis. This article uniquely dissects the integration of molecular signaling, Pol II degradation, and cancer model applications—offering new insights for apoptosis assays and cancer biology.

• Plerixafor (AMD3100): Unraveling CXCR4 Axis Modulation in...

  2025-09-23

  Explore the scientific foundations and advanced applications of Plerixafor (AMD3100), a potent CXCR4 chemokine receptor antagonist, in cancer metastasis inhibition, hematopoietic stem cell mobilization, and immune modulation. This review integrates recent mechanistic insights and comparative perspectives from emerging CXCR4 inhibitors.

• br Regulation of AHR Activity AHR activity is

  2025-03-03

  

  Regulation of AHR Activity AHR activity is regulated in various ways. First, AHR protein levels are controlled via ubiquitin-mediated proteosomal degradation: Ligand binding induces AHR ubiquitination and subsequent degradation by the proteasome [5]. AIP, a component of the AHR chaperone complex,

• brain metabolism The decreased AR mediated response has been

  2025-03-03

  

  The decreased βAR-mediated response has been attributed to different mechanisms, including an attenuation of PKA activation, an impaired generation of cyclic AMP, a reduced receptor density, and a less efficient coupling to adenylyl-cyclase [10]. However, currently there is no single molecular or ce

• Homoharringtonine Further evidence for action mechanism

  2025-03-03

  

  Further evidence for action mechanism was provided by assays using [3H]nisoxetine, a selective NET inhibitor used as standard radioligand for competitive binding experiments. The results showed dose-dependent blocking of [3H]nisoxetine binding by both xylazine and dexmedetomidine. Nisoxetine binds t

• Adenosine is a ubiquitous homeostatic

  2025-03-03

  

  Adenosine is a ubiquitous homeostatic substance released from most cells, including neurons and glias. Endogenous adenosine acts at four principal G-protein-associated receptor subtypes: A1, A2a, A2b and A3 (Ralevic and Burnstock, 1998). The stimulation of adenosine receptors by extracellular adenos

• Similarly Dilma et al tried to

  2025-03-03

  

  Similarly Dilmaç et al. [16] tried to assess the diagnostic value of adenosine deaminase activity in sputum of patients with pulmonary tuberculosis, their aim was to determine and compare sputum ADA activity in pulmonary tuberculosis, lung cancer and chronic obstructive pulmonary disease (COPD) pati

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